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Risk factors for overcorrection of severe hyponatremia: a post hoc analysis of the SALSA trial
- Source :
- Kidney Research and Clinical Practice, Vol 41, Iss 3, Pp 298-309 (2022)
- Publication Year :
- 2022
- Publisher :
- The Korean Society of Nephrology, 2022.
-
Abstract
- Background Hyponatremia overcorrection can result in irreversible neurologic impairment such as osmotic demyelination syndrome. Few prospective studies have identified patients undergoing hypertonic saline treatment with a high risk of hyponatremia overcorrection. Methods We conducted a post hoc analysis of a multicenter, prospective randomized controlled study, the SALSA trial, in 178 patients aged above 18 years with symptomatic hyponatremia (mean age, 73.1 years; mean serum sodium level, 118.2 mEq/L). Overcorrection was defined as an increase in serum sodium levels by >12 or 18 mEq/L within 24 or 48 hours, respectively. Results Among the 178 patients, 37 experienced hyponatremia overcorrection (20.8%), which was independently associated with initial serum sodium level (≤110, 110–115, 115–120, and 120–125 mEq/L with 7, 4, 2, and 0 points, respectively), chronic alcoholism (7 points), severe symptoms of hyponatremia (3 points), and initial potassium level (
Details
- Language :
- English, Korean
- ISSN :
- 22119132 and 22119140
- Volume :
- 41
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Kidney Research and Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1a61f2a86c9c4575b39ac480e07370f5
- Document Type :
- article
- Full Text :
- https://doi.org/10.23876/j.krcp.21.180