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Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Authors :
C. S. Gallagher
N. Mäkinen
H. R. Harris
N. Rahmioglu
O. Uimari
J. P. Cook
N. Shigesi
T. Ferreira
D. R. Velez-Edwards
T. L. Edwards
S. Mortlock
Z. Ruhioglu
F. Day
C. M. Becker
V. Karhunen
H. Martikainen
M.-R. Järvelin
R. M. Cantor
P. M. Ridker
K. L. Terry
J. E. Buring
S. D. Gordon
S. E. Medland
G. W. Montgomery
D. R. Nyholt
D. A. Hinds
J. Y. Tung
the 23andMe Research Team
J. R. B. Perry
P. A. Lind
J. N. Painter
N. G. Martin
A. P. Morris
D. I. Chasman
S. A. Missmer
K. T. Zondervan
C. C. Morton
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Uterine leiomyomata (UL) or fibroids are neoplasms of the uterine smooth muscle associated with heavy menstrual bleeding and other female reproductive tract morbidity. Here, the authors identify eight previously undescribed genetic loci for UL and further look into genetic overlap with heavy menstrual bleeding and endometriosis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1a4318550c6403d984ad10ede4120c7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12536-4