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Evaluation of rK-39 strip test using urine for diagnosis of visceral leishmaniasis in an endemic area in Bangladesh

Authors :
Haque Rashidul
Jamil Kazi M
Itoh Makoto
Podder Milka
Alam Mohammad Shafiul
Khan Md Gulam Musawwir
Wagatsuma Yukiko
Source :
Parasites & Vectors, Vol 3, Iss 1, p 114 (2010)
Publication Year :
2010
Publisher :
BMC, 2010.

Abstract

Abstract Diagnosis of visceral leishmaniasis (VL) by demonstration of parasites in tissue smears obtained from bone marrow, spleen or lymph nodes is risky, painful, and difficult. The rK-39 strip test is widely used for the diagnosis of VL using blood/serum samples in endemic countries. The aim of the study was to evaluate the rK-39 strip test using urine sample as a non-invasive means for the diagnosis of VL. The rk-39 strip test was performed using urine from 100 suspected VL cases along with 25 disease control (malarial febrile cases) and 50 healthy control (from endemic and non-endemic areas). All the VL suspected cases were positive with the rK-39 strip test using serum. The sensitivity and specificity of the rK-39 strip test using urine samples was 95% and 93.3%, respectively, compared to serum based rK-39 test. The findings suggest that the urine based rK-39 test could be a practical and efficient tool for the diagnosis of VL patients in rural areas, particularly where resources are limited.

Details

Language :
English
ISSN :
17563305
Volume :
3
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Parasites & Vectors
Publication Type :
Academic Journal
Accession number :
edsdoj.19f37f59ffd249de8376def847b35fb7
Document Type :
article
Full Text :
https://doi.org/10.1186/1756-3305-3-114