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Rapid response to emerging biomedical challenges and threats

Authors :
Marek Grabowski
Joanna M. Macnar
Marcin Cymborowski
David R. Cooper
Ivan G. Shabalin
Miroslaw Gilski
Dariusz Brzezinski
Marcin Kowiel
Zbigniew Dauter
Bernhard Rupp
Alexander Wlodawer
Mariusz Jaskolski
Wladek Minor
Source :
IUCrJ, Vol 8, Iss 3, Pp 395-407 (2021)
Publication Year :
2021
Publisher :
International Union of Crystallography, 2021.

Abstract

As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural data has given rise to multiple resources dedicated to assessing the correctness and quality of structural data and models. Here, an approach to evaluate the massive amounts of such data using the resource https://covid19.bioreproducibility.org is described, which offers a template that could be used in large-scale initiatives undertaken in response to future biomedical crises. Broader use of the described methodology could considerably curtail information noise and significantly improve the reproducibility of biomedical research.

Details

Language :
English
ISSN :
20522525
Volume :
8
Issue :
3
Database :
Directory of Open Access Journals
Journal :
IUCrJ
Publication Type :
Academic Journal
Accession number :
edsdoj.19ec1f7d95c4318919a6c73913467c7
Document Type :
article
Full Text :
https://doi.org/10.1107/S2052252521003018