Back to Search Start Over

Pharmacomicrobiomics and Drug–Infection Interactions: The Impact of Commensal, Symbiotic and Pathogenic Microorganisms on a Host Response to Drug Therapy

Authors :
Norma Torres-Carrillo
Erika Martínez-López
Nora Magdalena Torres-Carrillo
Andres López-Quintero
José Miguel Moreno-Ortiz
Anahí González-Mercado
Itzae Adonai Gutiérrez-Hurtado
Source :
International Journal of Molecular Sciences, Vol 24, Iss 23, p 17100 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Microorganisms have a close relationship with humans, whether it is commensal, symbiotic, or pathogenic. Recently, it has been documented that microorganisms may influence the response to drug therapy. Pharmacomicrobiomics is an emerging field that focuses on the study of how variations in the microbiome affect the disposition, action, and toxicity of drugs. Two additional sciences have been added to complement pharmacomicrobiomics, namely toxicomicrobiomics, which explores how the microbiome influences drug metabolism and toxicity, and pharmacoecology, which refers to modifications in the microbiome as a result of drug administration. In this context, we introduce the concept of “drug-infection interaction” to describe the influence of pathogenic microorganisms on drug response. This review analyzes the current state of knowledge regarding the relevance of microorganisms in the host’s response to drugs. It also highlights promising areas for future research and proposes the term “drug-infection interaction” as an extension of pharmacomicrobiomics.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
24
Issue :
23
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.1994549d3f5a41e7af4fa0bc8acbf256
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms242317100