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Decreased Serum Brain-Derived Neurotrophic Factor Concentrations 72 Hours Following Marathon Running
- Source :
- Frontiers in Physiology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Background: Physical exercise has been linked to beneficial effects on brain plasticity. One potential key mechanism for this relationship is an exercise-induced increase of brain-derived neurotrophic factor (BDNF). However, the kinetics of BDNF in athletes during training phase, extreme exercise competition, and recovery period have not been investigated so far.Methods: We assessed serum BDNF concentrations in 51 marathon runners (23% female, mean age 43 years) in a longitudinal study design over a period of 6 months. Assessments were conducted during the training period before the marathon and after the marathon race during short-term (24 to 72 h) and long-term (3 months) follow-ups. Potential confounders (fitness level, sex, and platelet count) were included in subsequent linear-model analyses.Results: Linear mixed-model analyses revealed a main effect of time for BDNF concentrations over the study period (F(4,89.389) = 4.296, p = 0.003). Values decreased significantly with the lowest values at 72 h after the marathon compared to baseline (p = 0.025), a finding that was more pronounced in the larger male cohort.Conclusion: Prolonged exercise induces a significant decrease in serum BDNF concentration 72 h post-exercise. We assume that this observation is mainly driven by regenerative mechanisms and a higher muscular utilization.
Details
- Language :
- English
- ISSN :
- 1664042X
- Volume :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.19445090f374dbbabcd246009300ebb
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fphys.2021.668454