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Needle tract seeding and abdominal recurrence following pre-treatment biopsy of gastrointestinal stromal tumors (GIST): results of a systematic review

Authors :
Jens Jakob
Rashad Salameh
David Wichmann
Nicos Charalambous
Anne-Christine Zygmunt
Inga Kreisel
Judith Heinz
Michael Ghadimi
Ulrich Ronellenfitsch
Source :
BMC Surgery, Vol 22, Iss 1, Pp 1-9 (2022)
Publication Year :
2022
Publisher :
BMC, 2022.

Abstract

Abstract Background Gastrointestinal stromal tumors (GIST) are rare abdominal tumors. Pretreatment biopsies may be used to diagnose a GIST and enable tailored treatment. Some experts are skeptical about biopsies because they fear tumor cell seeding. The objective of this study was to determine if pretreatment biopsy is associated with increased tumor recurrence. Methods We performed a systematic literature search and included studies assessing the oncological outcome of GIST patients who underwent a pre-treatment core needle biopsy or fine needle aspiration. We assessed methodological quality with the Newcastle-Ottawa-Scale for non-randomized studies. This review was registered in the PROSPERO database (CRD42021170290). Results Three non-randomized studies and eight case reports comprising 350 patients were eligible for inclusion. No prospective study designed to answer the review question was found. One case of needle tract seeding after percutaneous core needle biopsy of GIST was reported. None of the studies reported an increased rate of abdominal recurrence in patients with pretreatment biopsy. Conclusions The existing evidence does not indicate a relevant risk of needle tract seeding or abdominal recurrence after pre-treatment biopsy of GIST. Biopsy can safely be done to differentiate GIST from other tumors and to select the most appropriate treatment.

Details

Language :
English
ISSN :
14712482
Volume :
22
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Surgery
Publication Type :
Academic Journal
Accession number :
edsdoj.19424c34e2904af8b0db38e78bf0fcf2
Document Type :
article
Full Text :
https://doi.org/10.1186/s12893-022-01648-2