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Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets

Authors :
Hitesh Chopra
Protity Shuvra Dey
Debashrita Das
Tanima Bhattacharya
Muddaser Shah
Sidra Mubin
Samka Peregrine Maishu
Rokeya Akter
Md. Habibur Rahman
Chenmala Karthika
Waheed Murad
Naeem Qusty
Safaa Qusti
Eida M. Alshammari
Gaber El-Saber Batiha
Farag M. A. Altalbawy
Mona I. M. Albooq
Badrieah M. Alamri
Source :
Molecules, Vol 26, Iss 16, p 4998 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across the globe for its therapeutic and medicinal benefits. The active moiety of Curcuma longa is curcumin and has gained importance in various treatments of various disorders such as antibacterial, antiprotozoal, cancer, obesity, diabetics and wound healing applications. Several techniques had been exploited as reported by researchers for increasing the therapeutic potential and its pharmacological activity. Here, the dictum is the new room for the development of physicochemical, as well as biological, studies for the efficacy in target specificity. Here, we discussed nanoformulation techniques, which lend support to upgrade the characters to the curcumin such as enhancing bioavailability, increasing solubility, modifying metabolisms, and target specificity, prolonged circulation, enhanced permeation. Our manuscript tried to seek the attention of the researcher by framing some solutions of some existing troubleshoots of this bioactive component for enhanced applications and making the formulations feasible at an industrial production scale. This manuscript focuses on recent inventions as well, which can further be implemented at the community level.

Details

Language :
English
ISSN :
14203049 and 74391836
Volume :
26
Issue :
16
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.192e000742d743918362a703accf40b8
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules26164998