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MORPHOLOGICAL PATTERNS OF DEVELOPMENT AND PREVENTION OF EXPERIMENTAL EPIDURAL FIBROSIS
- Source :
- Паёми Сино, Vol 24, Iss 2, Pp 176-184 (2022)
- Publication Year :
- 2022
- Publisher :
- Avicenna Tajik State Medical University, 2022.
-
Abstract
- Objective: To identify the morphological patterns of development and prevention of experimental epidural fibrosis based on the shape of the dural sac in the area of laminectomy. Methods: Male Wistar rats aged 4-5 months underwent laminectomy at the level of L6-S1. The animals were divided into two groups with 7 animals per group. In the main group (Group A) the animals were treated with Antiadhesin® gel applied to the wound to prevent the development of epidural fibrosis, while in the group of comparison (Group B), the gel was not applied. Another 7 healthy animals were used as a control group. The animals were taken out of experiment on the 28th day. Histological slides stained with hematoxylin-eosin were used to measure the width and length of the dural sac, its area, perimeter, and calculate its deformity index. Results: In group B at the level of laminectomy, the ratio of the width to length of the dural sac was significantly higher than in the control group (p
Details
- Language :
- English, Russian
- ISSN :
- 20740581 and 29596327
- Volume :
- 24
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Паёми Сино
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.18ee2654ae4d42dea08360e00085c033
- Document Type :
- article
- Full Text :
- https://doi.org/10.25005/2074-0581-2022-24-2-176-184