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Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma

Authors :
Laura Pinton
Samantha Solito
Elena Masetto
Marina Vettore
Stefania Canè
A. Della Puppa
Susanna Mandruzzato
Source :
OncoImmunology, Vol 7, Iss 7 (2018)
Publication Year :
2018
Publisher :
Taylor & Francis Group, 2018.

Abstract

Meningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease. Although the presence of an immune cell infiltrate has been documented in these tumors, a clear phenotypical and functional characterization of the immune web is missing. Here, we performed an extensive immunophenotyping of peripheral blood and fresh tumor tissue at surgery by multiparametric flow cytometry in 34 meningioma patients, along with immunosuppressive activity of sorted cells of myeloid origin. Four subsets of myeloid cells, phenotypically corresponding to myeloid-derived suppressor cells (MDSCs) are detectable in the blood and in the tumor tissue of patients and three of them are significantly expanded in the blood of patients, but show no evidence of suppressive activity. At the tumor site, a large leukocyte infiltrate is present, predominantly constituted by CD33+ myeloid cells, largely composed of macrophages endowed with suppressive activity and significantly expanded in grade II meningioma patients as compared to grade I.

Details

Language :
English
ISSN :
2162402X
Volume :
7
Issue :
7
Database :
Directory of Open Access Journals
Journal :
OncoImmunology
Publication Type :
Academic Journal
Accession number :
edsdoj.18ea33f0a89c4228a89c90c718e74446
Document Type :
article
Full Text :
https://doi.org/10.1080/2162402X.2018.1440931