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Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation

Authors :
Priscila Cilene León Bueno de Camargo
José Eduardo Afonso Jr
Marcos Naoyuki Samano
Milena Marques Pagliarelli Acencio
Leila Antonangelo
Ricardo Henrique de Oliveira Braga Teixeira
Source :
Jornal Brasileiro de Pneumologia, Vol 40, Iss 4, Pp 425-428 (2014)
Publication Year :
2014
Publisher :
Sociedade Brasileira de Pneumologia e Tisiologia, 2014.

Abstract

Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients.

Details

Language :
English, Portuguese
ISSN :
18063756 and 18063713
Volume :
40
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Jornal Brasileiro de Pneumologia
Publication Type :
Academic Journal
Accession number :
edsdoj.189bb52835384ed8934e923bc389ee09
Document Type :
article
Full Text :
https://doi.org/10.1590/S1806-37132014000400011