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Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma

Authors :
Darci Phillips
Magdalena Matusiak
Belén Rivero Gutierrez
Salil S. Bhate
Graham L. Barlow
Sizun Jiang
Janos Demeter
Kimberly S. Smythe
Robert H. Pierce
Steven P. Fling
Nirasha Ramchurren
Martin A. Cheever
Yury Goltsev
Robert B. West
Michael S. Khodadoust
Youn H. Kim
Christian M. Schürch
Garry P. Nolan
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

PD-1 blockade is effective for only a subset of patients with cutaneous T cell lymphomas. Here, the authors report a spatial biomarker that uses immune and cancer cell topography to predict response to PD-1 blockade in this disease.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.185b95b3ae0241efb2f75ef0ed8fba8c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26974-6