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CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT

Authors :
Arindam Chaudhury
Shebna Cheema
Joseph M. Fachini
Natee Kongchan
Guojun Lu
Lukas M. Simon
Tao Wang
Sufeng Mao
Daniel G. Rosen
Michael M. Ittmann
Susan G. Hilsenbeck
Chad A. Shaw
Joel R. Neilson
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Epithelial-to-mesenchymal transition is a key process in tumorigenesis but little is known about the molecular mechanism regulating such process at the translational level. Here, the authors identify a subset of mRNAs important for this process that are specifically modulated by the RNA-binding protein CELF1.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.184a2be1bc5d42b7a1899779ab2debb3
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms13362