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Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma

Authors :
Kirk M. Druey
Morgan McCullough
Ramaswamy Krishnan
Source :
Journal of Fungi, Vol 6, Iss 2, p 88 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

We review three recent findings that have fundamentally altered our understanding of causative mechanisms underlying fungal-related asthma. These mechanisms may be partially independent of host inflammatory processes but are strongly dependent upon the actions of Alp1 on lung structural cells. They entail (i) bronchial epithelial sensing of Alp1; (ii) Alp1-induced airway smooth muscle (ASM) contraction; (iii) Alp1-induced airflow obstruction. Collectively, these mechanisms point to Alp1 as a new target for intervention in fungal asthma.

Details

Language :
English
ISSN :
2309608X
Volume :
6
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of Fungi
Publication Type :
Academic Journal
Accession number :
edsdoj.18331aa6f1454fbe3cdb20ae0edfa5
Document Type :
article
Full Text :
https://doi.org/10.3390/jof6020088