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Novel therapeutic agents in clinical trials: emerging approaches in cancer therapy

Authors :
Deepak Chandra Joshi
Anurag Sharma
Sonima Prasad
Karishma Singh
Mayank Kumar
Kajal Sherawat
Hardeep Singh Tuli
Madhu Gupta
Source :
Discover Oncology, Vol 15, Iss 1, Pp 1-40 (2024)
Publication Year :
2024
Publisher :
Springer, 2024.

Abstract

Abstract Novel therapeutic agents in clinical trials offer a paradigm shift in the approach to battling this prevalent and destructive disease, and the area of cancer therapy is on the precipice of a trans formative revolution. Despite the importance of tried-and-true cancer treatments like surgery, radiation, and chemotherapy, the disease continues to evolve and adapt, making new, more potent methods necessary. The field of cancer therapy is currently witnessing the emergence of a wide range of innovative approaches. Immunotherapy, including checkpoint inhibitors, CAR-T cell treatment, and cancer vaccines, utilizes the host’s immune system to selectively target and eradicate malignant cells while minimizing harm to normal tissue. The development of targeted medicines like kinase inhibitors and monoclonal antibodies has allowed for more targeted and less harmful approaches to treating cancer. With the help of genomics and molecular profiling, “precision medicine” customizes therapies to each patient’s unique genetic makeup to maximize therapeutic efficacy while minimizing unwanted side effects. Epigenetic therapies, metabolic interventions, radio-pharmaceuticals, and an increasing emphasis on combination therapy with synergistic effects further broaden the therapeutic landscape. Multiple-stage clinical trials are essential for determining the safety and efficacy of these novel drugs, allowing patients to gain access to novel treatments while also furthering scientific understanding. The future of cancer therapy is rife with promise, as the integration of artificial intelligence and big data has the potential to revolutionize early detection and prevention. Collaboration among researchers, and healthcare providers, and the active involvement of patients remain the bedrock of the ongoing battle against cancer. In conclusion, the dynamic and evolving landscape of cancer therapy provides hope for improved treatment outcomes, emphasizing a patient-centered, data-driven, and ethically grounded approach as we collectively strive towards a cancer-free world.

Details

Language :
English
ISSN :
27306011
Volume :
15
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Discover Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.1794742c1bfd4630b3d8325ec0c1be5a
Document Type :
article
Full Text :
https://doi.org/10.1007/s12672-024-01195-7