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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
- Source :
- Molecular Genetics and Metabolism Reports, Vol 31, Iss , Pp 100872- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
Details
- Language :
- English
- ISSN :
- 22144269
- Volume :
- 31
- Issue :
- 100872-
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular Genetics and Metabolism Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.17931b37180404cb8818baa30ee324c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ymgmr.2022.100872