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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

Authors :
Anouk M. La Rose
Anouk G. Groenen
Benedek Halmos
Venetia Bazioti
Martijn G.S. Rutten
Kishore A. Krishnamurthy
Mirjam H. Koster
Niels J. Kloosterhuis
Marieke Smit
Rick Havinga
Gilles Mithieux
Fabienne Rajas
Folkert Kuipers
Maaike H. Oosterveer
Marit Westerterp
Source :
Molecular Genetics and Metabolism Reports, Vol 31, Iss , Pp 100872- (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

Details

Language :
English
ISSN :
22144269
Volume :
31
Issue :
100872-
Database :
Directory of Open Access Journals
Journal :
Molecular Genetics and Metabolism Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.17931b37180404cb8818baa30ee324c
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ymgmr.2022.100872