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Amyotrophic Lateral Sclerosis—The Complex Phenotype—From an Epidemiological Perspective: A Focus on Extrapyramidal and Non-Motor Features

Authors :
Daniele Urso
Stefano Zoccolella
Valentina Gnoni
Giancarlo Logroscino
Source :
Biomedicines, Vol 10, Iss 10, p 2537 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND) and has emerged, among the disorders, with the largest increase in incidence in Western countries. Although the typical clinical phenotype of ALS involves simultaneous upper and lower motor neurons, there is growing evidence that the neurodegeneration during the course of the disease can also involve other motor and non-motor regions. In this review, we analyzed and discussed available data from epidemiological population-based studies on extrapyramidal and non-motor features during the course of ALS.

Details

Language :
English
ISSN :
22279059
Volume :
10
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.1745ba35a1fc4156ae601b6a87bbf23d
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines10102537