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Analyzing serum tryptophan metabolites in patients with gestational diabetes mellitus
- Source :
- Romanian Journal of Laboratory Medicine, Vol 31, Iss 4, Pp 251-262 (2023)
- Publication Year :
- 2023
- Publisher :
- Sciendo, 2023.
-
Abstract
- Introduction: Although pregnancy is a physiological condition, the secretion of diabetogenic hormones such as growth hormone, corticotropin-releasing hormone, placental lactogen hormone, prolactin and progesterone from the placenta could lead to insulin resistance (IR). In Metabolic Syndrome, obesity and Type1&2 diabetes, a shift in the kynurenine pathway (KP) towards IDO activation is observed. The activation of the IDO leads to the activation of the Aryl hydrocarbon receptor (AhR) and Interleukin-6 (IL-6) also, which may also induce some effects like insulin resistance, β-cell disfunction and increased gluconeogenesis. We hypothesized that the overactivation of IDO and some KP enzymes would be observed in GDM patients, in a similar manner to metabolic syndrome, prediabetes, and diabetes patients.
- Subjects :
- ogtt
gestational diabetes mellitus
tryptophan-kynurenine pathway
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 22845623
- Volume :
- 31
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Romanian Journal of Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.16bb41bcd3d461a9fd2b44dcefa1250
- Document Type :
- article
- Full Text :
- https://doi.org/10.2478/rrlm-2023-0027