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Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- The systemic understanding of oncogenic kinase signalling is still limited. Here, the authors combine chemical proteomics with functional screens to assess the impact of oncogenic Src on the expressed kinome and identify SGK1 as a critical mediator of Src-induced cell transformation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.16b94020768b4b0886330aa70dd0da0d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-08154-1