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Ferroptosis-related alternative splicing signatures as potential biomarkers for predicting prognosis and therapy response in gastric cancer

Authors :
Gang Long
Zhiyong Li
Yue Gao
Xu Zhang
Xiyang Cheng
Irankunda Eric Daniel
Lisha Zhang
Dawei Wang
Zhengtian Li
Source :
Heliyon, Vol 10, Iss 14, Pp e34381- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Ferroptosis is linked to various tumor biological traits, and alternative splicing (AS), a crucial step in mRNA processing, plays a role in the post-transcriptional regulation of ferroptosis-related genes (FRGs). A least absolute shrinkage and selection operator (LASSO) penalized Cox regression analysis was utilized to build a prognostic signature based on 12 AS events (p 0.4, FDR

Details

Language :
English
ISSN :
24058440
Volume :
10
Issue :
14
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.16a7d8d00b3248e9be3e8b19ad1f62c5
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e34381