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Association between Anemia and Risk of Parkinson Disease
- Source :
- Behavioural Neurology, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background and Objective. People with anemia have higher rates of developing Parkinson disease (PD) than the general population. Previous epidemiological studies have invested the risk of PD in patients with anemia. However, the findings are still inconclusive. Therefore, we did a systematic review with meta-analysis to clarify the association between anemia and risk of PD. Methods. We systematically searched articles on electronic databases such as PubMed, Embase, Scopus, and Google Scholar between January 1, 2000 and July 30, 2020. Articles were independently evaluated by two authors. We included observational studies (case-control and cohort) and calculated the risk ratios (RRs) for associated with anemia and PD. Heterogeneity among the studies was assessed using the Q and I2 statistic. We utilized the random-effect model to calculate the overall RR with 95% CI. Results. A total of 342 articles were identified in the initial searches, and 7 full-text articles were evaluated for eligibility. Three articles were further excluded for prespecified reasons including insufficient data and duplications, and 4 articles were included in our systematic review and meta-analysis. A random effect model meta-analysis of all 4 studies showed no increased risk of PD in patients with anemia (N=4, RRadjusted=1.17 (95% CI: 0.94-1.45, p=0.15). However, heterogeneity among the studies was significant (I2=92.60, p=
- Subjects :
- Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 09534180 and 18758584
- Volume :
- 2021
- Database :
- Directory of Open Access Journals
- Journal :
- Behavioural Neurology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.16875f35fa6468fbd626828258a6adf
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2021/8360627