Expression and role of ERAP1 in placental tissues of preeclampsia

Objective This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen). Results The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia. Conclusion These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.