Back to Search
Start Over
Expression and role of ERAP1 in placental tissues of preeclampsia
- Source :
- Hypertension in Pregnancy, Vol 39, Iss 2, Pp 165-171 (2020)
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- Objective This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis. Methods ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen). Results The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia. Conclusion These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.
- Subjects :
- preeclampsia
erap1
pathogenesi
Gynecology and obstetrics
RG1-991
Subjects
Details
- Language :
- English
- ISSN :
- 10641955 and 15256065
- Volume :
- 39
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Hypertension in Pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.16638886de174b78a2bd69809fe44969
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/10641955.2020.1749848