Back to Search Start Over

Antiviral Activity of the Marine Haptophyta Diacronema lutheri

Antiviral Activity of the Marine Haptophyta Diacronema lutheri

Authors :
Eleonora Montuori
Annalisa Ambrosino
Gerardo Della Sala
Costanza Ragozzino
Gianluigi Franci
Carla Zannella
Anna De Filippis
Donatella de Pascale
Massimiliano Galdiero
Chiara Lauritano
Source :
Marine Drugs, Vol 23, Iss 1, p 12 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

There are still several viral infections affecting a considerable number of the world’s population, causing thousands of deaths each year. There are no drugs available for most viral infections and for many not even a vaccine. The marine kingdom is characterized by a huge chemical diversity; however, there is currently on the market only one drug derived from the sea with antiviral properties, called Ara-A. In the current study, we used a solid phase extraction method (SPE) to obtain pre-purified fractions from Diacronema lutheri raw extracts. We tested both raw extracts and fractions against enveloped and non-enveloped viruses. Results showed an antiviral activity of fraction C of D. lutheri against the herpes simplex virus type 1 (HSV-1 strain SC16). Liquid chromatography coupled with untargeted high-resolution tandem mass spectrometry (LC-HRMS2) were employed to chart the metabolite distribution in all SPE fractions and pinpoint molecular families unique (or almost unique) to the bioactive fraction. Sulfoquinovosyl di- and monoacylglycerols (SQDGs and SQMGs) and di- and monogalactosyl monoacylglycerols (DGMGs and MGMGs) represent the largest groups of compounds in fraction C and they are likely responsible for the antiviral properties of this fraction.

Details

Language :
English
ISSN :
16603397
Volume :
23
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.163ad877d63f464f922cf6c52e8007ab
Document Type :
article
Full Text :
https://doi.org/10.3390/md23010012