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Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome

Authors :
Salma Fourati
Annick Hamon
Rita Daclat
Joe-Elie Salem
Katell Peoc’h
Johanne Le Beyec
Francisca Joly
Jean-Marc Lacorte
Source :
Nutrients, Vol 15, Iss 18, p 3982 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quantified apolipoprotein B-48 (ApoB-48), which is exclusively synthesized by enterocytes and secreted associated with dietary lipids and investigated the relationship between ApoB-48 and clinical and biological data as well as PN dependence. A total of 51 adult patients were included, 36 of whom were PN-dependent. We found a robust positive correlation between circulating ApoB-48 and residual small bowel length, which was also found in the subgroup of patients with jejunocolic anastomosis. Fasting ApoB-48 levels were significantly lower in PN-dependent patients than in PN-weaned patients and negatively correlated with parenteral nutrition dependence. Our results suggest that ApoB-48 could be proposed as a marker of intestinal absorptive function and could be an interesting follow-up marker in patients with SBS.

Details

Language :
English
ISSN :
20726643
Volume :
15
Issue :
18
Database :
Directory of Open Access Journals
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
edsdoj.16337c0a6a6a4f949a1409c32a0312f6
Document Type :
article
Full Text :
https://doi.org/10.3390/nu15183982