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Efficacy of botulinum toxin type B (rimabotulinumtoxinB) in patients with cervical dystonia previously treated with botulinum toxin type A: A post-marketing observational study in Japan
- Source :
- eNeurologicalSci, Vol 25, Iss , Pp 100374- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- To date, efficacy data on botulinum toxin type B (rimabotulinumtoxinB) in patients with cervical dystonia (CD) previously treated with botulinum toxin type A in a large population are lacking; thus, we aimed to evaluate type B efficacy in this patient population. In a post-marketing observational cohort study, 150 patients previously treated with botulinum toxin type A were enrolled, of whom 138 were followed up for 1 year after the initial type B injection. Final observation data were available for 122 patients. Efficacy was evaluated using the Toronto Western Spasmodic Torticollis Rating Scale. Total score improved from 39.9 at baseline to 34.3 at 4 weeks after the first injection, and pain score improved from 8.9 to 7.9. Improvements were maintained through six further injections in two subpopulations: patients who showed resistance to botulinum toxin type A and patients who were not type A resistant but switched to type B. For a number of patients, even low doses (
Details
- Language :
- English
- ISSN :
- 24056502
- Volume :
- 25
- Issue :
- 100374-
- Database :
- Directory of Open Access Journals
- Journal :
- eNeurologicalSci
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.160c2045227b4c5fb2abdf6b88488561
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ensci.2021.100374