Back to Search Start Over

Fluorescence Spectroscopy of Enantiomeric Amide Compounds Enforced by Chiral Light

Authors :
Alessandro Belardini
Emilija Petronijevic
Ramin Ghahri
Daniele Rocco
Fabiana Pandolfi
Concita Sibilia
Leonardo Mattiello
Source :
Applied Sciences, Vol 11, Iss 23, p 11375 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Chirality, the absence of mirror symmetry, governs behavior in most biologically important molecules, thus making the chiral recognition of great importance in the pharmaceutical and agrochemical industries, as well as medicine. Chiral molecules can be characterized by means of optical experiments based on chiro-optical excitation of molecules. Specifically, chiral absorptive materials differently absorb left- and right-circular polarized light, i.e., they possess circular dichroism (CD). Unfortunately, the natural CD of most molecules is very low and lies in the ultraviolet range. Fluorescence-detected CD is a fast and sensitive tool for investigation of chiral molecules which emit light; ultralow CD in absorption can be detected as the difference in emission. In this work, we perform fluorescence-detected CD on novel chiral amide compounds, designed specifically for visible green emission; we synthesize two enantiomeric fluorescent compounds using low-cost starting compounds and easy purification. We investigate different solutions of the enantiomers at different concentrations, and we show that the fluorescence of the intrinsically chiral compounds depends on the polarization state of the penetrating light, which is absorbed at 400 nm and emits across the green wavelength range. We believe that these compounds can be coupled with plasmonic nanostructures, which further shows promise in applications regarding chiral sensing or chiral emission.

Details

Language :
English
ISSN :
20763417
Volume :
11
Issue :
23
Database :
Directory of Open Access Journals
Journal :
Applied Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.16089509b114025aa12a460c5039c53
Document Type :
article
Full Text :
https://doi.org/10.3390/app112311375