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Correlation of Sarcopenia with Coronary Artery Disease Severity and Pericoronary Adipose Tissue Attenuation: A Coronary CT Study

Authors :
Domenico Albano
Caterina Beatrice Monti
Giovanni Antonio Risoleo
Giacomo Vignati
Silvia Rossi
Edoardo Conte
Daniele Andreini
Francesco Secchi
Stefano Fusco
Massimo Galia
Paolo Vitali
Salvatore Gitto
Carmelo Messina
Luca Maria Sconfienza
Source :
Tomography, Vol 10, Iss 11, Pp 1744-1753 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Objective: To investigate the association between sarcopenia, as appraised with CT-derived muscle metrics, and cardiovascular status, as assessed via coronary CT angiography (CCTA) using the Coronary Artery Disease-Reporting and Data System (CAD-RADS) and with pericoronary adipose tissue (pCAT) metrics. Methods: A retrospective observational study conducted on patients who underwent CCTA. The cross-sectional area (CSA) and attenuation values of the paravertebral muscles at the T8 level and the pectoralis major muscles at the T6 level were measured. The patient height was employed for the normalization of the skeletal muscle CSA. The pCAT attenuation around the coronary arteries was assessed, and the CAD severity was graded using the CAD-RADS reporting system. Regression analyses were performed to assess the impact of demographics, clinical factors, and CT variables on the CAD-RADS and pCAT. Results: A total of 220 patients were included (132 males, median age 65 years). Regression analyses showed the associations of CAD with age and sex (p < 0.001). Familiarity with CAD was related to the left anterior descending artery pCAT (p = 0.002) and circumflex artery pCAT (p = 0.018), whereas age was related to the left anterior descending artery pCAT (p = 0.032). Weak positive correlations were found between the lower muscle density and lower pCAT attenuation (ρ = 0.144–0.240, p < 0.039). Conclusions: This study demonstrated weak associations between the sarcopenia indicators and the cardiovascular risk, as assessed by the CAD severity and pCAT inflammation. However, these correlations were not strong predictors of CAD severity, as age and traditional cardiovascular risk factors overshadowed the impact of sarcopenia in the cardiovascular risk assessment.

Details

Language :
English
ISSN :
2379139X and 23791381
Volume :
10
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Tomography
Publication Type :
Academic Journal
Accession number :
edsdoj.15f5c21aa26241b29d5ad2e8be9702eb
Document Type :
article
Full Text :
https://doi.org/10.3390/tomography10110128