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MAIT cells contribute to protection against lethal influenza infection in vivo

Authors :
Bonnie van Wilgenburg
Liyen Loh
Zhenjun Chen
Troi J. Pediongco
Huimeng Wang
Mai Shi
Zhe Zhao
Marios Koutsakos
Simone Nüssing
Sneha Sant
Zhongfang Wang
Criselle D’Souza
Xiaoxiao Jia
Catarina F. Almeida
Lyudmila Kostenko
Sidonia B. G. Eckle
Bronwyn S. Meehan
Axel Kallies
Dale I. Godfrey
Patrick C. Reading
Alexandra J. Corbett
James McCluskey
Paul Klenerman
Katherine Kedzierska
Timothy S. C. Hinks
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute to the protective host immune response to influenza virus infection.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.15ac8dd044648a69319eb56458d539f
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07207-9