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Central Nervous System Disorders with Auto-Antibodies in People Living with HIV

Authors :
Giacomo Stroffolini
Cristiana Atzori
Daniele Imperiale
Mattia Trunfio
Giovanni Di Perri
Andrea Calcagno
Source :
Microorganisms, Vol 12, Iss 9, p 1758 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Abstract: People living with HIV (PLWH) may present atypical neurological complications. Recently, autoimmune manifestations of the central nervous system (CNS) have been described. We retrospectively described the features of PLWH presenting with acute neurological symptoms with positive anti-CNS antibodies. We analyzed relevant CSF characteristics. Twelve patients were identified, with demyelinating, inflammatory, or no MRI lesions. We observed CSF inflammatory features. Aspecific CSF anti-CNS antibodies were found in all subjects and a specific antibody (second-level blotting panel) was found in one. The cases presented a slow resolution of symptoms with sequelae. More studies are needed to better describe the spectrum and prognosis of autoimmune CNS diseases in PLWH.

Details

Language :
English
ISSN :
12091758, 20762607, and 68743580
Volume :
12
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
edsdoj.159a8d29e9474be68743580d3eadd9f6
Document Type :
article
Full Text :
https://doi.org/10.3390/microorganisms12091758