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3D digital holographic polarimetry of laser speckle fields formed by polycrystalline blood films: a tool for differential diagnosis of thyroid pathology

Authors :
Olexander Ushenko
Olexander Bilookyi
Jun Zheng
Alexander Dubolazov
Olexander Olar
Yurii Ushenko
Iryna Soltys
Ivan Mikirin
Valeriy Skliarchuk
Zhebo Chen
Source :
Frontiers in Physics, Vol 12 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

The principles and effectiveness of the method of laser polarization interferometry of dehydrated blood films (facies) for the differential diagnosis of thyroid pathology have been studied. For this purpose, a theoretical description of the processes of formation and layer-by-layer phase scanning of the polarization structure of speckle fields in the blood facies of donors and patients with nodular goiter, autoimmune thyroiditis, and papillary cancer has been developed for the first time. A statistical analysis of holographically reconstructed maps of polarization ellipticity of the singly scattered component of the speckle field was conducted. Based on this analysis, the most sensitive markers for the diagnosis and differentiation of thyroid pathology were identified. Excellent diagnostic accuracy (91%–93%) and very good differentiation accuracy (86%–89%) were achieved for nodular goiter, autoimmune thyroiditis, and papillary cancer.

Details

Language :
English
ISSN :
2296424X
Volume :
12
Database :
Directory of Open Access Journals
Journal :
Frontiers in Physics
Publication Type :
Academic Journal
Accession number :
edsdoj.157cc3df7746dabae55ee92d8a3b07
Document Type :
article
Full Text :
https://doi.org/10.3389/fphy.2024.1426469