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Initial or salvage treatment with apatinib shows promise against radioiodine-refractory differentiated thyroid carcinoma
- Source :
- European Thyroid Journal, Vol 11, Iss 2, Pp 1-9 (2023)
- Publication Year :
- 2023
- Publisher :
- Bioscientifica, 2023.
-
Abstract
- Objective: Sorafenib and lenvatinib have been recommended as standard tyro sine kinase inhibitors (TKIs) for progressive radioiodine-refractory differentiated thyroid carcinoma (RR-DTC). However, their efficacy remains limited with unresolved drug resistance. Therefore, we conceived this open-label study based on real-world evidence to investigate the efficacy and safety of apatinib in patients wi th progressive RR-DTC. Methods: Off-label use of apatinib as either initial treatment or salvage treatment for sorafenib resistance was investigated. The primary endpoint was progression-free survival (PFS) and the secondary endpoints included objective r esponse rate (ORR), overall survival (OS), and safety. Results: For all 28 enrolled patients, the median PFS was 15.1 months, w ith an ORR of 69.6%. The median OS was not reached at the data cut-off. In det ail, the median PFS of 17.3 months and the ORR of 75% were determined in patients with TKI-naive RR-DTC (initial treatment group, n = 14). And, in patients with first-line sorafenib-resistant RR-DTC (salvage treatment group, n = 14), a median PFS of 12.0 months was reached, with an ORR of 45.5%. In the salvage treatment group, the media n OS from the start of apatinib administration was 20.6 months, reaching 89.1 month s from sorafenib treatment initiation. Adverse events at grade 3 or higher occur red in 64.3% of all subjects treated with apatinib. Conclusions: This study demonstrated that apatinib shows promise against RR- DTC with tolerable toxicity, representing a novel initial treatment for progressive RR-DTC and effective salvage treatment for RR-DTC resistant to sorafenib.
Details
- Language :
- English
- ISSN :
- 22350802
- Volume :
- 11
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- European Thyroid Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.156b85cbb0814fc2ac505b2705653a41
- Document Type :
- article
- Full Text :
- https://doi.org/10.1530/ETJ-21-0065