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From systems biology to P4 medicine: applications in respiratory medicine
- Source :
- European Respiratory Review, Vol 27, Iss 147 (2018)
- Publication Year :
- 2018
- Publisher :
- European Respiratory Society, 2018.
-
Abstract
- Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field.
- Subjects :
- Diseases of the respiratory system
RC705-779
Subjects
Details
- Language :
- English
- ISSN :
- 09059180 and 16000617
- Volume :
- 27
- Issue :
- 147
- Database :
- Directory of Open Access Journals
- Journal :
- European Respiratory Review
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1563e6d9b8234c468eb2fa8156ea854a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1183/16000617.0110-2017