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From systems biology to P4 medicine: applications in respiratory medicine

Authors :
Guillaume Noell
Rosa Faner
Alvar Agustí
Source :
European Respiratory Review, Vol 27, Iss 147 (2018)
Publication Year :
2018
Publisher :
European Respiratory Society, 2018.

Abstract

Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field.

Details

Language :
English
ISSN :
09059180 and 16000617
Volume :
27
Issue :
147
Database :
Directory of Open Access Journals
Journal :
European Respiratory Review
Publication Type :
Academic Journal
Accession number :
edsdoj.1563e6d9b8234c468eb2fa8156ea854a
Document Type :
article
Full Text :
https://doi.org/10.1183/16000617.0110-2017