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In Silico Study of Anticancer Activity of Red Betel Leaves Bioactive Compounds against Colon Cancer Marker Proteins

Authors :
Mutmainnah Umar
Mega Safithri
Rahadian Pratama
Source :
Hayati Journal of Biosciences, Vol 30, Iss 1 (2022)
Publication Year :
2022
Publisher :
Bogor Agricultural University, 2022.

Abstract

Colon cancer or colorectal cancer is one of the major health problems in the world. Previous research has proven that red betel leaves extract has anticancer activity against breast cancer cells. The study aimed to look at the potential of compounds contained in red betel ethyl acetate fraction as anticancer substances for colon cancer by conducting in silico tests through the docking of three colon cancer biomarker receptors against eight red betel leaves compounds. The parameters of binding affinity energy and inhibition constant used in the molecular docking analysis showed that there are several compounds that have the potential as inhibitors against colon cancer marker proteins to inhibit the development of colorectal cancer and have high bioavalibility as oral drugs. Based on in silico test it is known that the compound N-1,N-9-Bis [E-(2-nitophenyl) methylene] non anedihydrazide has the highest inhibition of human leukotriene A4 hydrolase receptor with binding affinity energy of 11.3160 Kcal/mol. The next compound is 4-({4,6-Bis[3R,5S)-3,5-diamino-1-piperydinyl]-1,3,5-traizin-2-yl}amino) benzenosulfon amide which has the highest inhibition in Chek1 with binding affinity energy of 9.7110 Kcal/mol, and the compound 4-(4-methoxy-phenylamino)-2,3-dihydro-1H-4a, 9-diaza-cyclopenta (b) fluorine-10-carbonitrile has the highest inhibition in the Bcl 2 navitoclax analog receptor with binding affinity energy of 8.4470 Kcal/mol.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English, Indonesian
ISSN :
19783019 and 20864094
Volume :
30
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Hayati Journal of Biosciences
Publication Type :
Academic Journal
Accession number :
edsdoj.151071a929f74dad830c7b4963d6cb93
Document Type :
article
Full Text :
https://doi.org/10.4308/hjb.30.1.113-121