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Advances of stem cell based-therapeutic approaches for tendon repair

Authors :
Lidi Liu
Jennifer Hindieh
Daniel J. Leong
Hui B. Sun
Source :
Journal of Orthopaedic Translation, Vol 9, Iss C, Pp 69-75 (2017)
Publication Year :
2017
Publisher :
Elsevier, 2017.

Abstract

Tendon injuries are significant clinical problems. Current treatments often result in incomplete repair or healing, which may lead to reduced function and rupture. Stem cell-based therapy is a promising intervention for tendon repair. In this article, we attempt to provide a brief overview on the recent progress in the field, current understanding of the underlying mechanisms of the approach, and the potential of stem cell-based therapies beyond cell implantation. We conclude the review by sharing our viewpoints on the challenges, opportunities, and future directions of this approach. The translational potential of this article: This paper reviews recent progress on stem cell-based therapeutic approaches for tendon repair, which highlights its translational potential and challenges.

Details

Language :
English
ISSN :
2214031X
Volume :
9
Issue :
C
Database :
Directory of Open Access Journals
Journal :
Journal of Orthopaedic Translation
Publication Type :
Academic Journal
Accession number :
edsdoj.15091df6a4f14b4d86543a85d9519a8b
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jot.2017.03.007