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Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies

Authors :
Jean François Valarcher
Sara Hägglund
Katarina Näslund
Luc Jouneau
Ester Malmström
Olivier Boulesteix
Anne Pinard
Dany Leguéré
Alain Deslis
David Gauthier
Catherine Dubuquoy
Vincent Pietralunga
Aude Rémot
Alexander Falk
Ganna Shevchenko
Sara Bergström Lind
Claudia Von Brömssen
Karin Vargmar
Baoshan Zhang
Peter D. Kwong
María Jose Rodriguez
Marga Garcia Duran
Isabelle Schwartz-Cornil
Geraldine Taylor
Sabine Riffault
Source :
Vaccines, Vol 9, Iss 3, p 236 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

The induction of long-lasting clinical and virological protection is needed for a successful vaccination program against the bovine respiratory syncytial virus (BRSV). In this study, calves with BRSV-specific maternally derived antibodies were vaccinated once, either with (i) a BRSV pre-fusion protein (PreF) and MontanideTM ISA61 VG (ISA61, n = 6), (ii) BRSV lacking the SH gene (ΔSHrBRSV, n = 6), (iii) a commercial vaccine (CV, n = 6), or were injected with ISA61 alone (n = 6). All calves were challenged with BRSV 92 days later and were euthanized 13 days post-infection. Based on clinical, pathological, and proteomic data, all vaccines appeared safe. Compared to the controls, PreF induced the most significant clinical and virological protection post-challenge, followed by ΔSHrBRSV and CV, whereas the protection of PreF-vaccinated calves was correlated with BRSV-specific serum immunoglobulin (Ig)G antibody responses 84 days post-vaccination, and the IgG antibody titers of ΔSHrBRSV- and CV-vaccinated calves did not differ from the controls on this day. Nevertheless, strong anamnestic BRSV- and PreF-specific IgG responses occurred in calves vaccinated with either of the vaccines, following a BRSV challenge. In conclusion, PreF and ΔSHrBRSV are two efficient one-shot candidate vaccines. By inducing a protection for at least three months, they could potentially improve the control of BRSV in calves.

Details

Language :
English
ISSN :
2076393X
Volume :
9
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.14e8581d0527445b8ffbe4eb17e80d8b
Document Type :
article
Full Text :
https://doi.org/10.3390/vaccines9030236