Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

The development of new drugs to treat COVID-19 continues to be of critical importance. This paper describes a new in-cell assay to screen for inhibitors of SARSCoV-2 in live cells. 8 new compounds are reported along with a crystal structure of a key viral protease, Mpro, in complex with one of the newly discovered compounds.