Analysis of effect of hematopoietic stem cell mobilization and collection in 67 healthy pediatric donors

Objective To evaluate the effect of hematopoietic stem cell mobilization and collection in healthy pediatric donors. Methods 67 healthy pediatric donors were included in this study.According to the donor/recipient （D/R） body weight ratio （BWR）， they were divided into three groups： D/R BWR2 group （n = 14）. The mobilization， collection effect and adverse reactions of bone marrow and peripheral blood stem cells were compared among all groups. Results The quantity of mononuclear cells （MNCs） of bone marrow stem cells collected in the D/R BWR2 group （both P < 0.001）. There was no significant difference in the quantity of bone marrow CD34+ cells among three groups （all P > 0.05）. The quantity of MNCs of peripheral blood stem cells in the D/R BWR>2 group was significantly higher than those in the D/R BWR2 group was significantly higher than that in the D/R BWR