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The role of CRF family peptides in the regulation of food intake and anxiety-like behavior
- Source :
- Biomolecular Concepts, Vol 2, Iss 4, Pp 275-280 (2011)
- Publication Year :
- 2011
- Publisher :
- De Gruyter, 2011.
-
Abstract
- Corticotropin-releasing factor (CRF) and the urocortins (UCN1, UCN2, and UCN3) belong to the CRF family of peptides and are the major regulators of the adaptive response to internal and external stresses. The actions of CRF and UCNs are mediated through two receptor subtypes: CRF receptor 1 (CRFR1) and CRFR2. Their physiological roles, among other functions, include the regulation of food intake and anxiety-like behavior. In this review, we describe the progress that has been made towards understanding how anxiety- and depression-like behavior and food intake are regulated by CRF, UCN1, UCN2, and UCN3.
Details
- Language :
- English
- ISSN :
- 18685021 and 1868503X
- Volume :
- 2
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Biomolecular Concepts
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.141f3439b834d009d8acab2a86a727c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/bmc.2011.022