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Emerging therapeutic strategies to enhance HDL function
- Source :
- Lipids in Health and Disease, Vol 10, Iss 1, p 175 (2011)
- Publication Year :
- 2011
- Publisher :
- BMC, 2011.
-
Abstract
- Abstract Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD). The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT). New insights in HDL biology and RCT have allowed the development of promising agents aimed to increase HDL function and promote atherosclerosis regression. In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD.
- Subjects :
- Nutritional diseases. Deficiency diseases
RC620-627
Subjects
Details
- Language :
- English
- ISSN :
- 1476511X
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Lipids in Health and Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.13ed06486e4f469ebf175fabe6a1e0fe
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/1476-511X-10-175