Clinical and pathological features of papillary renal cell carcinoma and prognostic value of its type-1 and type-2 subtypes

Introduction and objectives: Papillary renal cell carcinoma (PRCC) accounts for 10–15% of renal tumors in adults. This type of tumor contains more than 75% of tubulo-papillary structures and is divided histologically into two subtypes. The distinction between these two subtypes is essential because of their prognostic value. The aim of this study was to compare the prognostic significance of the PRCC subtypes. Patients and methods: This retrospective study included 34 patients operated for PRCC between January 2000 and December 2012. Clinical data including presenting symptoms, preoperative findings, pathological features, treatment and patient outcome were taken from the patients’ medical records as well as from radiological analysis based on computed tomography (CT) findings. A second analysis of the histological slides was made in doubtful cases to clarify the histological subtype. Results: PRCC was found in 12.7% of 267 patients operated for renal tumors during the study period. The patients’ mean age was 62.4 years with a male predominance (sex ratio 3.6). All tumors were unilateral with a mean size of 6.9 cm. There was no clinical or radiological sign suggestive of this histological type, however, 80% of the tumors had an enhancement