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Registry randomised trials: a methodological perspective

Authors :
Christopher M Reid
Susannah Ahern
Ian Harris
Steven Y C Tong
Angela L Brennan
Dorota A Doherty
Carol Hodgson
Stephen McDonald
Jennifer Reilly
Jane Shrapnel
Charmaine S Tam
Leonie Wilcox
Anitha Balagurunathan
Belinda E Butcher
Source :
BMJ Open, Vol 13, Iss 3 (2023)
Publication Year :
2023
Publisher :
BMJ Publishing Group, 2023.

Abstract

Registry randomised clinical trials (RRCTs) have the potential to provide pragmatic answers to important clinical questions. RRCTs can be embedded into large population-based registries or smaller single site registries to provide timely answers at a reduced cost compared with traditional randomised controlled trials. RRCTs can take a number of forms in addition to the traditional individual-level randomised trial, including parallel group trials, platform or adaptive trials, cluster randomised trials and cluster randomised stepped-wedge trials. From an implementation perspective, initially it is advantageous to embed RRCT into well-established registries as these have typically already overcome any issues with end point validation and adjudication. With advances in data linkage and data quality, RRCTs can play an important role in answering clinical questions in a pragmatic, cost-effective way.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
20446055
Volume :
13
Issue :
3
Database :
Directory of Open Access Journals
Journal :
BMJ Open
Publication Type :
Academic Journal
Accession number :
edsdoj.13cd5e7584ee4fb898a52f4d603eec2c
Document Type :
article
Full Text :
https://doi.org/10.1136/bmjopen-2022-068057