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mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

Authors :
Xiaolei Ding
Wilhelm Bloch
Sandra Iden
Markus A. Rüegg
Michael N. Hall
Maria Leptin
Linda Partridge
Sabine A. Eming
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

mTOR regulates cell growth via a protein complex including mTORC1 and mTORC2, but their role in skin morphogenesis is unclear. Here, the authors delete mTORC1 and mTORC2 from the epidermis and see epidermal deficiencies but both mTORCs play distinct roles in skin morphogenesis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.13c10d0d38324a9ba4a52ca390cb9bc2
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms13226