Autologous Hematopoietic Cell Transplant as an Effective Treatment Modality for Systemic Sclerosis and Multiple Myeloma

Hamda Memon,1 Ricardo Parrondo,2 Julianna Schreurs,2 Ernesto Ayala,2 Madiha Iqbal2 1Department of Family Medicine, Geisinger Health in Wilkes Barre, Wilkes Barre, Pennsylvania, USA; 2Division of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida, USACorrespondence: Madiha Iqbal, Department of Medicine,Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, 4500 San Pablo road, Jacksonville, FL, 32224, USA, Email Iqbal.madiha@mayo.eduAbstract: Systemic sclerosis (SSc) is a multi-system disease characterized by a dysregulated immune system. Autologous hematopoietic cell transplantation (AHCT) is the only treatment that has been shown to confer significant benefit in controlling disease and improving survival for patients with SSc. A diagnosis of multiple myeloma (MM) after the diagnosis of SSc is rare and optimal treatment in such cases remains unclear. We here report a case of a female patient who was diagnosed with MM while she was undergoing evaluation for AHCT due to SSc. A novel conditioning regimen for AHCT, with therapeutic efficacy in SSc and MM was offered to the patient, resulting in long term remission of both diseases.Keywords: systemic sclerosis, autologous hematopoietic cell transplantation, multiple myeloma