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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

Authors :
Chen Yao
George Chen
Ci Song
Joshua Keefe
Michael Mendelson
Tianxiao Huan
Benjamin B. Sun
Annika Laser
Joseph C. Maranville
Hongsheng Wu
Jennifer E. Ho
Paul Courchesne
Asya Lyass
Martin G. Larson
Christian Gieger
Johannes Graumann
Andrew D. Johnson
John Danesh
Heiko Runz
Shih-Jen Hwang
Chunyu Liu
Adam S. Butterworth
Karsten Suhre
Daniel Levy
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Genetic variation can influence levels of disease-related plasma proteins and, thus, contribute to the pathogenesis of complex diseases. Here, the authors perform genome-wide QTL analysis for 71 plasma proteins to identify causal proteins for coronary heart disease and provide a molecular QTL browser.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1352d0a9c4818b111c7a3955ca2ac
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-05512-x