The effect of combined topical and intravenous administration of dimephosphonon the ischemic skin flap vitality and engraftment of free autograft

It was demonstrated experimentally on mice that dimephosphon as well as actovegin, trental and mexidol in combined -one-fold local and two-fold (with 4h interval) intravenous administration - 24 h after pedicle flap increases its vitality. According to their protective activity the studied drugs can be placed as follows: trental > dimephosphon = mexidol > actovegin. According to the range of their therapeutic effect they can be placed like this - dimephosphon > trental > actovegin > mexidol. Trental is more effective when given in combination appart from dimephosphon, actovegin and mexidol. Topical and intraperitoneal administration of dimephosphon and referent actovegin during 20 days increases engraftment of free dermal autograft (ADA) and epithelization of the lesion (after origin of scab) on the 15-20 days of the investigation. According to their activity the preparations can be divided as follows by the 15th day - actovegin > trental = dimephosphon; by the 20th day - actovegin > dimephosphon = trental. Dimephosphon apart from actovegin and trental prevents the purulence in the area of free ADA.