Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

Authors :: Tadashi Maemura
Makoto Kuroda
Tammy Armbrust
Seiya Yamayoshi
Peter J. Halfmann
Yoshihiro Kawaoka
Source :: mBio, Vol 12, Iss 5 (2021)
Publication Year :: 2021
Publisher :: American Society for Microbiology, 2021.
Abstract: Viruses infect cells mainly via specific receptors at the cell surface. Antibody-dependent enhancement (ADE) of infection is an alternative mechanism of infection for viruses to infect immune cells that is mediated by antibodies and IgG receptors (FcγRs).

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