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Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative

Authors :
Maximilian T. Löffler
Chotigar Ngarmsrikam
Paula Giesler
Gabby B. Joseph
Zehra Akkaya
John A. Lynch
Nancy E. Lane
Michael Nevitt
Charles E. McCulloch
Thomas M. Link
Source :
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background Obesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could be associated with subcutaneous fat (SCF) around the knee. Purpose of the study was to investigate the effect of weight loss on synovitis progression and to assess whether SCF around the knee mediates the relationship between weight loss and synovitis progression. Methods We included 234 overweight and obese participants (body mass index [BMI] ≥ 25 kg/m2) from the Osteoarthritis Initiative (OAI) with > 10% weight loss (n = 117) or stable overweight (

Details

Language :
English
ISSN :
14712474
Volume :
25
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Musculoskeletal Disorders
Publication Type :
Academic Journal
Accession number :
edsdoj.128d7f85bef643e2babcec9a4adfb6b9
Document Type :
article
Full Text :
https://doi.org/10.1186/s12891-024-07397-y