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Brain activities of streptozotocin-induced diabetic Wistar rats treated with gliclazide: Behavioural, biochemical and histomorphology studies
- Source :
- IBRO Neuroscience Reports, Vol 12, Iss , Pp 271-279 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Gliclazide (GLD), a sulphonylurea is efficacious in the treatment of diabetes type-2. However, there is limited information on its activity in the brain, especially in diabetics. This research investigated the brain activities of GLD following streptozotocin-induced diabetes in Wistar rats. Twenty five adult male Wistar rats (200–250 g) were grouped (n = 5) as: Control (distilled water, 5 mL/kg) and GLD (150 mg/kg) groups; and the diabetic groups, untreated streptozotocin (STZ, 35 mg/kg), and STZ (35 mg/kg) treated with GLD (150 mg/kg) for two and four weeks, and already on high fat diet. The animals’ body weights and blood glucose levels were checked weekly. After the experimental duration, spontaneous alternation and novel object recognition tests were carried out and the animals sacrificed. Perfusion with phosphate buffered saline preceded brain excision for biochemical analyses, with halves fixed in 10% neutral buffered formalin for histology. Compared with the control, results showed (p
Details
- Language :
- English
- ISSN :
- 26672421
- Volume :
- 12
- Issue :
- 271-279
- Database :
- Directory of Open Access Journals
- Journal :
- IBRO Neuroscience Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.124e6f8ea74d4130b186ab338eca48f9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ibneur.2022.04.001