Back to Search Start Over

Extracellular Nucleic Acids in the Diagnosis and Progression of Colorectal Cancer

Authors :
Jakub Styk
Gergely Buglyó
Ondrej Pös
Ádám Csók
Beáta Soltész
Peter Lukasz
Vanda Repiská
Bálint Nagy
Tomáš Szemes
Source :
Cancers, Vol 14, Iss 15, p 3712 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Colorectal cancer (CRC) is the 3rd most common malignant neoplasm worldwide, with more than two million new cases diagnosed yearly. Despite increasing efforts in screening, many cases are still diagnosed at a late stage, when mortality is high. This paper briefly reviews known genetic causes of CRC (distinguishing between sporadic and familial forms) and discusses potential and confirmed nucleic acid biomarkers obtainable from liquid biopsies, classified by their molecular features, focusing on clinical relevance. We comment on advantageous aspects such as better patient compliance due to blood sampling being minimally invasive, the possibility to monitor mutation characteristics of sporadic and hereditary CRC in a disease showing genetic heterogeneity, and using up- or down-regulated circulating RNA markers to reveal metastasis or disease recurrence. Current difficulties and thoughts on some possible future directions are also discussed. We explore current evidence in the field pointing towards the introduction of personalized CRC management.

Details

Language :
English
ISSN :
20726694
Volume :
14
Issue :
15
Database :
Directory of Open Access Journals
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
edsdoj.1226b9b493284d4d822a13412e0922ac
Document Type :
article
Full Text :
https://doi.org/10.3390/cancers14153712