Back to Search
Start Over
Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?
- Source :
- Schizophrenia Research and Treatment, Vol 2016 (2016)
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p=0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p=0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.
- Subjects :
- Psychiatry
RC435-571
Subjects
Details
- Language :
- English
- ISSN :
- 20902085 and 20902093
- Volume :
- 2016
- Database :
- Directory of Open Access Journals
- Journal :
- Schizophrenia Research and Treatment
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1211ed97e85426392ddf44bea3f906d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2016/1942828